AHA Coding Clinic® for ICD-10-CM and ICD-10-PCS - 2026 Quarter 4; Ask the Editor

HIV Infection with Immune Reconstitution Inflammatory Syndrome (IRIS)

A patient with advanced HIV with diffuse cutaneous leishmaniasis due to Leishmania panamensis was admitted with worsening bilateral lower extremity pain and difficulty walking secondary to multiple diffuse raised hyperpigmented macules coalescing over the dorsum of the patient’s bilateral hands and feet. The provider noted that the patient’s CD4 count increased to 184 while on antiretroviral therapy (ART) and diagnosed the patient with immune reconstitution inflammatory syndrome (IRIS) secondary to initiation of highly active antiretroviral therapy (HAART). What is the appropriate code assignment for IRIS secondary to HAART in a patient with HIV? ...

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