AHA Coding Clinic® for ICD-10-CM and ICD-10-PCS - 2025 Issue 4; ICD-10-PCS New/Revised Codes Section X—New Technology
Introduction of New Therapeutic Substances
In table XW0, Introduction of Anatomical Regions, 7 new substance values were added to identify the substances listed below. These substances have the qualifier value New Technology Group 11.Device/Substance/Technology F Valoctocogene Roxaparvovec-rvox P Aztreonam-avibactam Anti-infective Q Iloprost R Letetresgene Autoleucel T Rozanolixizumab-noli Monoclonal Antibody V Xanomeline and Trospium Chloride W Fosfomycin Anti-infective Valoctocogene Roxaparvovec-rvoxValoctocogene roxaparvovec-rvox is an intravenous infusion gene therapy vector that is used to treat adults with severe hemophilia A (congenital Factor VIII deficiency with Factor VIII activity <1 IU/dL) without antibodies to adeno-associated virus serotype 5. It is designed to introduce a functional copy...
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Article Overview
This premium article is about newly added therapeutic substance values in a procedure coding table and the clinical contexts associated with those additions. It is relevant to coders, billing professionals, CDI staff, and health information teams who need to track quarterly or annual coding updates affecting infusion, injection, immunotherapy, antibiotic, and other treatment-related reporting. The article provides a high-level overview of the substances and their intended uses without serving as a coding reference by itself.
Why This Topic Matters
Updates to procedure tables can affect code selection, documentation review, and compliant reporting. Understanding which therapeutic substances were added helps coding and clinical teams stay current with system changes and related treatment categories.
Article Sections
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Overview of new substance values
Introduces the table update and the newly added substance values tied to a specific qualifier. The section identifies the broad set of therapeutic categories covered in the article.
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Individual therapeutic substance summaries
Provides separate clinical overviews for each newly added substance, including the general treatment area and route or administration context. The section covers infusion, injection, and other therapy types across several specialties.
What You Will Learn
- Which therapeutic substance categories were newly added to the table
- What broad clinical uses are associated with each new substance
- Which care settings and administration routes are discussed
- How the update fits into procedure coding maintenance
Who Should Read This
- Medical coders
- Coding auditors
- CDI specialists
- Billing staff
- Revenue cycle teams
- Health information management professionals
Code Ranges Discussed
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