COVID-19 October Update (October 2020)

October 2020 Special Edition COVID-19 October Update As we approach the season for influenza (flu) and respiratory syncytial virus (RSV) infections, clinicians need to be able to rapidly distinguish these two seasonal infections from infections caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Ordinarily, a test panel that evaluates these four viruses would be reported using Current Procedural Terminology (CPT®) code 87631, Infectious agent detection by nucleic acid (DNA or RNA); respiratory virus (eg, adenovirus, influenza virus, coronavirus, metapneumovirus, parainfluenza virus, respiratory syncytial virus, rhinovirus), includes multiplex reverse transcription, when performed, and multiplex amplified probe technique, multiple...

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Note:  The following article synopsis was NOT provided by the AMA. It was created by Find-A-Code/innoviHealth.

Article Overview

This October 2020 CPT update explains coding changes tied to COVID-19 testing and related respiratory virus laboratory services. It is aimed at coders, laboratory billing staff, and clinicians who report infectious disease testing, and it covers new and revised CPT and PLA codes, updated Microbiology and Immunology guidance, and clarifications affecting laboratory test reporting.

Why This Topic Matters

The article matters because it documents a set of CPT and PLA updates used to distinguish SARS-CoV-2 testing from other respiratory virus testing and to clarify reporting guidance for infectious agent studies. These changes affect laboratory compliance, claim accuracy, and consistent reporting across COVID-19-related diagnostic services.

Article Sections

  1. October 2020 Special Edition

    Introductory material placing the update in the context of seasonal respiratory virus testing and COVID-19-related coding changes.

  2. Infectious-Agent Detection

    Overview of the laboratory coding update, including new and revised guidance for infectious-agent testing and related reporting categories.

  3. Immunology

    Revisions and additions affecting immunology-related infectious agent reporting in the CPT code set.

  4. Microbiology

    Updated Microbiology subsection content covering infectious agent detection, parenthetical notes, and related reporting guidance.

  5. New Codes and Updated Microbiology Guidelines

    Discussion of newly established and revised CPT respiratory testing codes and the associated guideline changes.

  6. Immunofluorescent Technique

    Background discussion of terminology and methodological distinctions relevant to infectious agent antigen testing.

  7. Direct Optical Observation

    Clarification of how direct optical observation is described and distinguished in the updated guidance.

  8. Single-Step vs Multiple-Step Techniques

    General discussion of historical terminology used for immunoassay methods and why the update addresses it.

  9. Changes Related to the Three Concepts

    Summary of how the guideline revisions, notes, and new code additions relate to the methodology discussion.

  10. Proprietary Laboratory Analyses

    Introduction to newly established PLA reporting for proprietary respiratory viral testing.

  11. Two PLA Codes Established

    Description of the PLA section changes, including how the proprietary tests are organized in the code set and appendix references.

  12. Clinical Example (87636)

    A combined clinical example and procedure description illustrating the type of scenario associated with this respiratory testing code.

  13. Clinical Example (87637)

    A combined clinical example and procedure description illustrating the type of scenario associated with this respiratory testing code.

  14. Clinical Example (87811)

    A combined clinical example and procedure description illustrating the type of scenario associated with this antigen testing code.

  15. Clinical Example (0240U)

    A combined clinical example and procedure description illustrating the type of scenario associated with this PLA code.

  16. Clinical Example (0241U)

    A combined clinical example and procedure description illustrating the type of scenario associated with this PLA code.

What You Will Learn

  • How the article organizes COVID-19-related updates across CPT and PLA coding.
  • Which sections of the CPT code set received updated microbiology and immunology guidance.
  • How the update frames respiratory viral testing changes in relation to SARS-CoV-2.
  • What categories of laboratory services are addressed by the new and revised coding guidance.
  • How the article presents the addition of proprietary laboratory analyses for respiratory virus testing.

Who Should Read This

  • Medical coders
  • Laboratory billing staff
  • Compliance teams
  • Pathology and laboratory professionals
  • Clinicians ordering infectious disease tests

Codes Discussed

Code Ranges Discussed

Modifiers Discussed


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