Pathology and Laboratory: Surgical Pathology (Q&A) (November 2018)

November 2018 page 11d Pathology and Laboratory: Surgical Pathology Question: What is the correct code to report a human papillomavirus (HPV) high-risk (HR) assay that is a qualitative in situ hybridization (ISH) analysis intended for the use on formalin-fixed, paraffin-embedded (FFPE) tissue stained with an automated staining instrument? The HPV mRNA probes 16, 18, and 33 are combined into one dispenser vial to make a cocktail; one slide is stained; and an interpretation of a positive or negative result is reported. Answer: Code 88365, In situ hybridization (eg, FISH), per specimen; initial single probe stain procedure, should be reported...

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Note:  The following article synopsis was NOT provided by the AMA. It was created by Find-A-Code/innoviHealth.

Article Overview

This article explains a surgical pathology coding question in the context of a laboratory assay performed on formalin-fixed, paraffin-embedded tissue with automated staining. It is useful for pathology coders, laboratory billing staff, and compliance teams who need to understand the general CPT reporting framework discussed in the guidance.

Why This Topic Matters

Pathology and laboratory coding often turns on how a test is performed and how results are reported. This Q&A helps readers identify the relevant CPT framework for a specific surgical pathology scenario without having to interpret the full premium discussion.

Article Sections

  1. November 2018 page 11d

    A single Q&A section covering a pathology and laboratory coding question from a November 2018 CPT Assistant issue. The discussion centers on surgical pathology reporting in a laboratory setting.

What You Will Learn

  • How this pathology and laboratory scenario is framed for CPT reporting
  • What general type of surgical pathology coding issue the article addresses
  • How the article situates the discussion within CPT Assistant guidance
  • Which coding framework is referenced for the laboratory assay described

Who Should Read This

  • Pathology coders
  • Laboratory billing staff
  • Compliance professionals
  • Clinical documentation specialists
  • Physician office coding staff

Codes Discussed


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