Reporting Chimeric Antigen Receptor T-Cell Therapy Services

May 2025 page 26 Reporting Chimeric Antigen Receptor T-Cell Therapy Services For the CPT 2025 code set, Category III codes 0537T-0540T were converted into new Category I codes 38225-38228 to report chimeric antigen receptor (CAR) T lymphocytes (T cells) (CAR-T) therapy. As a result, codes 0537T-0540T, which were established in 2019 to report CAR-T therapy, were deleted. In addition to the new codes, guidelines and parenthetical notes were added in the Hemic and Lymphatic Systems subsection of the Surgery section. This article provides an overview of these changes and the intent and reporting of the new codes. Cellular and...

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Note:  The following article synopsis was NOT provided by the AMA. It was created by Find-A-Code/innoviHealth.

Article Overview

This premium article explains the CPT 2025 update for chimeric antigen receptor T-cell therapy services. It is aimed at coding professionals and clinicians who need to understand the scope of the updated code family, the related Hemic and Lymphatic Systems guidance, and the broader categories of services that may be discussed alongside CAR-T reporting.

Why This Topic Matters

The article matters because it summarizes a coding update that replaced earlier temporary reporting codes with permanent ones and added supporting guidance in the CPT Surgery section. It helps readers understand where the topic fits within cellular and gene therapy reporting and which related service categories are addressed in the discussion.

Article Sections

  1. May 2025 page 26

    Publication and page reference information for the article.

  2. Reporting Chimeric Antigen Receptor T-Cell Therapy Services

    An overview of the CPT 2025 update for CAR-T therapy reporting and the addition of supporting guidance in the Surgery section.

  3. Cellular and Gene Therapies

    General background on cellular and gene therapy processes and the scope of the new CAR-T service family.

  4. Clinical Examples and Procedural Descriptions

    Representative scenarios and procedure narratives illustrating the kinds of services associated with the updated CAR-T code family.

What You Will Learn

  • How the article frames the CPT 2025 CAR-T therapy update
  • What general areas of service are discussed for cellular and gene therapies
  • Which supporting guideline topics are addressed with the new CAR-T reporting guidance
  • What types of clinical examples are included in the article

Who Should Read This

  • Medical coders
  • Coding auditors
  • Revenue cycle professionals
  • Physician practices
  • Hospital coding staff
  • Clinical documentation specialists

Codes Discussed

Code Ranges Discussed

Modifiers Discussed


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