Tissue Examination for Molecular Studies (Codes 88387, 88388) (October 2010)

October 2010 page 5 Tissue Examination for Molecular Studies (Codes 88387, 88388) Two codes were added in the Surgical Pathology subsection of the Pathology and Laboratory section in the CPT 2010 codebook to allow for the reporting of the macroscopic examination, dissection, and preparation of tissue for non-microscopic analytical studies that is necessary prior to molecular diagnostic testing. This article describes these new codes and their intended application New Codes 88387Macroscopic examination, dissection, and preparation of tissue for non-microscopic analytical studies (eg, nucleic acid-based molecular studies); each tissue preparation (eg, a single lymph node) Two parenthetical notes were added...

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Note:  The following article synopsis was NOT provided by the AMA. It was created by Find-A-Code/innoviHealth.

Article Overview

This CPT Assistant article from October 2010 covers newly added pathology coding guidance for tissue examination and preparation used before molecular diagnostic testing. It is relevant to pathologists, laboratory coders, and billing staff working with surgical pathology services, intraoperative consultation, and related specimen handling. The article also summarizes the CPT 2010 parenthetical guidance, the intended scope of the services, and illustrative clinical scenarios.

Why This Topic Matters

These updates help coding professionals recognize newly introduced pathology services associated with molecular testing workflows and understand how the CPT 2010 codebook framed their reporting. Accurate awareness of this guidance supports consistent coding for specimen preparation services in pathology and laboratory settings.

Article Sections

  1. New Codes

    Introduces the newly added pathology services and summarizes the general CPT 2010 context for their inclusion. It also notes related parenthetical guidance from the codebook.

  2. Background

    Provides general context for why the services were added and how they relate to molecular testing workflows. The section discusses the broader pathology and laboratory setting without focusing on specific code selection details.

  3. Clinical Example (Code 88387)

    Presents an illustrative scenario showing specimen handling and preparation in a molecular testing context. The example is intended to clarify the nature of the service in a practical setting.

  4. Clinical Example (Code 88388)

    Presents a second illustrative scenario involving related pathology workflow elements and intraoperative evaluation. The example shows how the service fits into a tissue examination process.

What You Will Learn

  • The general purpose of the newly added pathology services
  • How the article frames tissue examination and preparation in relation to molecular studies
  • The broader CPT 2010 context surrounding the new pathology guidance
  • The types of clinical scenarios used to illustrate the services

Who Should Read This

  • Pathologists
  • Laboratory coders
  • Medical coders
  • Billing staff
  • Pathology and laboratory compliance personnel

Codes Discussed

Code Ranges Discussed


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