CPT Knowledgebase - Jul 3, 2023

Programmed death-ligand 1 (PD-L1) expression is determined in formalin-fixed paraffin-embedded tissue slides by immunohistochemistry. All viable tumor cells are included (minimum 100 viable tumor cells). The pathologist evaluates using light microscopy. PD-L1 expression is determined as Tumor Proportion Score (TPS): percentage viable tumor cells showing partial or complete membrane staining. Cytoplasmic staining is excluded. Immune cell staining is reported separately (not included in TPS). Please confirm that 88360 is appropriate.

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