Irreversible Electroporation Ablation: New Codes for 2021 (March 2021)

March 2021 page 5 Irreversible Electroporation Ablation: New Codes for 2021 Irreversible electroporation (IRE) is a new technology used in cancer treatment. Similar to chemotherapy, IRE destroys cancer cells. Unlike chemotherapy, IRE destroys cells with ultra-short pulsed electrical current by creating permanent small pores (known as nanopores) in the cell membrane, disrupting homeostasis. For the Current Procedural Terminology (CPT®) 2021 code set, two new Category III codes (0600T, 0601T) were established to report IRE with imaging guidance, when performed. This article provides an overview of the intent and use of these new codes. Category III Codes  0600TAblation, irreversible...

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Note:  The following article synopsis was NOT provided by the AMA. It was created by Find-A-Code/innoviHealth.

Article Overview

This CPT Assistant article covers the introduction of new Category III coding for irreversible electroporation ablation in 2021. It is relevant to coding professionals, oncology practices, and procedural specialists who need to understand the scope of the new guidance, the settings described, and the general reporting context for this emerging cancer treatment technology.

Why This Topic Matters

The article helps readers identify the appropriate CPT framework for a newer ablation technology and understand how the 2021 update changed reporting within the CPT Category III code set.

Article Sections

  1. Category III Codes

    Introduces the new CPT Category III reporting options and describes the general scope of the update for irreversible electroporation ablation. The section also notes related imaging guidance considerations at a broad level.

  2. Clinical Example (0600T) / Description of Procedure (0600T)

    Presents a representative clinical scenario and associated procedural narrative for the percutaneous setting. The section illustrates the type of case context discussed for this reporting option.

  3. Clinical Example (0601T) / Description of Procedure (0601T)

    Presents a representative clinical scenario and associated procedural narrative for the open setting. The section illustrates the type of case context discussed for this reporting option.

What You Will Learn

  • The purpose of the 2021 CPT update for irreversible electroporation ablation
  • How the article frames the two new CPT Category III reporting options
  • The general distinction between the procedure settings described in the article
  • The types of clinical scenarios used to illustrate the new reporting guidance
  • How the article situates imaging guidance within the broader topic

Who Should Read This

  • Medical coders
  • Coding auditors
  • Physician practices
  • Oncology specialists
  • Surgical billing staff

Codes Discussed


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