New Codes for Reporting Neuromyelitis Optica and MOG Antibody Testing (April 2022)

April 2022 pages 3-4 New Codes for Reporting Neuromyelitis Optica and MOG Antibody Testing For the Current Procedural Terminology (CPT®) 2022 code set, several new codes have been added to the Immunology subsection in the Pathology and Laboratory section for reporting a variety of new antibody tests for severe autoimmune, inflammatory, and demyelinating central nervous disease. Prior to 2022, only nonspecific methodology-based codes were available. These new codes (86051-86053, 86362, 86363) allow for greater specificity, not only for the methodology being used for the test but also for the specific antibody being tested. This article provides an overview...

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Note:  The following article synopsis was NOT provided by the AMA. It was created by Find-A-Code/innoviHealth.

Article Overview

This April 2022 CPT Assistant article explains newly added pathology and laboratory coding for antibody testing related to severe autoimmune, inflammatory, and demyelinating central nervous disease. It is useful for laboratory coders, pathologists, and billing professionals who need to understand the scope of the new CPT code family, the testing methods referenced, and the clinical scenarios discussed at a high level.

Why This Topic Matters

These code additions affect how certain specialized immunology tests are represented in CPT and help distinguish test methodology and target antibody with greater specificity. The article is relevant for accurate reporting, lab workflow alignment, and understanding how the new coding structure fits clinical antibody testing.

Article Sections

  1. New Codes for Reporting Neuromyelitis Optica and MOG Antibody Testing

    Introduces the new CPT immunology codes added in 2022 and explains the general purpose of the update. It also frames the article around specialized antibody testing in pathology and laboratory services.

  2. Immunology

    Lists the newly established CPT codes and identifies the broad antibody-testing topics associated with them. The section also summarizes the clinical context for these laboratory tests at a general level.

  3. Clinical Examples and Description of Procedure

    Provides paired clinical scenarios and procedure overviews for the newly introduced codes. The material illustrates typical laboratory testing workflows without serving as a substitute for the full article.

What You Will Learn

  • The general purpose of the new CPT immunology code additions
  • Which broad antibody-testing topics are addressed in the article
  • How the article frames the relationship between laboratory methodology and specific antibody testing
  • The types of clinical scenarios used to illustrate the new codes
  • How the article situates these changes within pathology and laboratory reporting

Who Should Read This

  • Medical coders
  • Laboratory billing staff
  • Pathologists
  • Revenue cycle professionals
  • Compliance teams

Codes Discussed

Code Ranges Discussed


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