AMA CPT® Assistant - 2018 Issue 9 (September)
Pathology and Laboratory: Molecular Pathology (Q&A) (September 2018)
September 2018 page 14d Pathology and Laboratory: Molecular Pathology Question: The laboratory performs genetic testing for the identification of sickle cell disease. When performing full gene sequencing first and proceeding to variant duplication/deletion using a single sample, can a laboratory report both CPT codes 81364 and 81363? If so, is a modifier necessary? Answer: It would be appropriate to report code 81364, HBB (hemoglobin, subunit beta) (eg, sickle cell anemia, beta thalassemia, hemoglobinopathy); full gene sequence, with code 81363, HBB (hemoglobin, subunit beta) (eg, sickle cell anemia, beta thalassemia, hemoglobinopathy); duplication/deletion variant(s), for sequencing followed by duplication/deletion analysis. Use...
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