Pathology and Laboratory: Genomic Sequencing Procedures and Other Molecular Multianalyte Assays (Q&A) (September 2018)

September 2018 page 15 Pathology and Laboratory: Genomic Sequencing Procedures and Other Molecular Multianalyte Assays Question: The laboratory offers deletion/duplication analysis for single gene analysis and various panels of genes via an array platform methodology. Should deletion/duplication analysis panels be handled in the same manner as the sequencing panels based on the genes being analyzed, or should code 81405, Molecular pathology procedure, Level 6 (eg, analysis of 6-10 exons by DNA sequence analysis, mutation scanning or duplication/deletion variants of 11-25 exons, regionally targeted cytogenomic array analysis), be reported for regionally targeted cytogenomic array analysis? Answer: The deletion/duplication CPT codes...

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Note:  The following article synopsis was NOT provided by the AMA. It was created by Find-A-Code/innoviHealth.

Article Overview

This article reviews coding questions in pathology and laboratory medicine related to genomic sequencing procedures and other molecular multianalyte assays. It focuses on how CPT guidance applies to deletion/duplication testing, array-based analyses, and panel-based molecular testing in the context of hereditary cardiac conditions. The discussion is aimed at coders, billing staff, and laboratory professionals who work with CPT molecular pathology services and supporting documentation.

Why This Topic Matters

The article helps readers understand how CPT molecular pathology guidance is applied to common laboratory testing scenarios so claims can be reported consistently and supported appropriately.

Article Sections

  1. Question and Answer: Deletion/Duplication Analysis Panels

    This section discusses a laboratory testing scenario involving deletion/duplication analysis, array-based methodology, and related molecular pathology reporting considerations. It addresses how the topic is framed within CPT molecular pathology services.

  2. Question and Answer: Comprehensive Cardiomyopathy Panel

    This section covers a panel-based genomic sequencing scenario involving hereditary cardiac testing and overlapping gene content. It presents the coding topic in the context of CPT guidance for molecular sequencing panels.

What You Will Learn

  • How the article frames deletion/duplication analysis within molecular pathology reporting
  • How panel-based genomic sequencing testing is discussed in CPT guidance
  • What general types of laboratory documentation issues are associated with unlisted molecular pathology reporting
  • How hereditary cardiomyopathy panel testing is presented in the context of CPT molecular pathology coding

Who Should Read This

  • Medical coders
  • Pathology and laboratory billing staff
  • Molecular diagnostics laboratories
  • Compliance and reimbursement professionals
  • Health care providers involved in genetic testing orders

Codes Discussed


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