AMA CPT® Assistant - 2015 Issue 12 (December)

Pathology and Laboratory: GSP and Other Molecular Multianalyte Assays (Bonus Q&A) (December 2015)

December 2015 page 19a Pathology and Laboratory: GSP and Other Molecular Multianalyte Assays Question: Does code 81420 encompass genomic sequence analysis involving single nucleotide polymorphism (SNPs) ("hot spots") only or does the code include only full sequencing tests? Is it appropriate to report molecular cytogenetic codes (eg, FISH) for microdeletion testing that involves deeper sequence analysis of circulating cell-free DNA rather than in situ analysis of cells for trisomy 21, 18, and 13? Answer: Code 81420, Fetal chromosomal aneuploidy (eg, trisomy 21, monosomy X) genomic sequence analysis panel, circulating cell-free fetal DNA in maternal blood, must include analysis of...

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CPT® Assistant content is the official source for CPT® coding guidance. It is an instrumental tool when appealing insurance denials and validating coding to auditors. Monthly issues and an extensive archive provide comprehensive guidance on proper CPT® coding for past, present and upcoming code set releases. Archives date back to 1990 for historical use of codes, changes, rationales, coding tips and trends in the industry.

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