Pathology and Laboratory: GSP and Other Molecular Multianalyte Assays (Bonus Q&A) (December 2015)

December 2015 page 19a Pathology and Laboratory: GSP and Other Molecular Multianalyte Assays Question: Does code 81420 encompass genomic sequence analysis involving single nucleotide polymorphism (SNPs) ("hot spots") only or does the code include only full sequencing tests? Is it appropriate to report molecular cytogenetic codes (eg, FISH) for microdeletion testing that involves deeper sequence analysis of circulating cell-free DNA rather than in situ analysis of cells for trisomy 21, 18, and 13? Answer: Code 81420, Fetal chromosomal aneuploidy (eg, trisomy 21, monosomy X) genomic sequence analysis panel, circulating cell-free fetal DNA in maternal blood, must include analysis of...

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Note:  The following article synopsis was NOT provided by the AMA. It was created by Find-A-Code/innoviHealth.

Article Overview

This bonus Q&A article addresses pathology and laboratory coding topics involving molecular multianalyte assays and selected CPT guidance. It is aimed at coders, lab billing staff, and compliance teams who need to understand the scope of the discussed tests, related CPT reporting considerations, and how the article frames testing scenarios in molecular diagnostics.

Why This Topic Matters

Laboratory coding for molecular testing can be nuanced, especially when services overlap with other assay types or involve evolving genomic methods. This article helps readers recognize which general CPT topics are being addressed so they can review the full guidance in context.

Article Sections

  1. December 2015 page 19a

    Introductory article page marker and the start of the bonus Q&A content for pathology and laboratory topics.

What You Will Learn

  • How the article frames CPT questions about molecular multianalyte assays
  • What broad testing scenarios are discussed in the Q&A format
  • Which general laboratory coding topics are covered in the article
  • How the article groups guidance for fetal and infectious disease molecular testing

Who Should Read This

  • Medical coders
  • Laboratory billing staff
  • Compliance professionals
  • Pathology practices
  • Revenue cycle teams

Codes Discussed


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