Therapeutic Drug Assays: 2021 Updates (January 2021)

January 2021 pages 8-9 Therapeutic Drug Assays: 2021 Updates For the Current Procedural Terminology (CPT®) 2021 code set, 10 new codes have been established in the Therapeutic Drug Assays subsection in the Pathology and Laboratory section to report therapeutic drug assays (TDA), which are tests performed to monitor levels of prescription or over-the-counter medications. To conduct a TDA, whole blood, serum, plasma, or cerebrospinal fluid is examined using quantitative testing to determine therapeutic or toxicology levels, which may be used to guide treatment. This article does not apply to urinary detection of qualitative or quantitative (definitive) assays for...

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Note:  The following article synopsis was NOT provided by the AMA. It was created by Find-A-Code/innoviHealth.

Article Overview

This article summarizes January 2021 CPT updates for therapeutic drug assay reporting in the Pathology and Laboratory section. It is aimed at coding professionals, laboratory staff, and compliance teams who need to understand the scope of the new therapeutic drug assay entries, the related parenthetical guidance, and the distinction between therapeutic monitoring and definitive drug testing.

Why This Topic Matters

These updates affect how laboratories and coders identify and report therapeutic drug assay services in 2021 CPT materials. Understanding the article helps readers recognize which assay topics were added, what related note structure was introduced, and where the article directs readers for broader testing considerations.

Article Sections

  1. January 2021 pages 8-9

    Introduces the 2021 CPT update context for therapeutic drug assays and explains the general scope of the changes discussed in the article.

  2. Therapeutic Drug Assays

    Reviews the therapeutic drug assay subsection updates, including newly established entries and related parenthetical guidance. The section also presents clinical examples and procedural descriptions illustrating the updated topic area.

What You Will Learn

  • The scope of 2021 CPT updates related to therapeutic drug assays
  • How the article frames therapeutic drug assay reporting within the Pathology and Laboratory section
  • Which categories of therapeutic drug monitoring topics were newly addressed
  • How the article distinguishes therapeutic drug assays from other drug testing topics at a high level
  • What kinds of clinical example material are included with the update

Who Should Read This

  • Medical coders
  • Laboratory professionals
  • Compliance teams
  • Revenue cycle staff
  • Coding educators

Codes Discussed

Code Ranges Discussed


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