AHA Coding Clinic® for HCPCS - 2026 Issue 1; For Your Information

New CPT Proprietary Laboratory Analyses (PLA) codes Effective April 1, 2026

New CPT PLA CodesCPT Code Long Descriptor Effective Date 0614U Inborn error of metabolism (primary mitochondrial disease), mitochondrial analysis of 4 enzyme complexes by stained blue native polyacrylamide gel electrophoresis (PAGE), frozen tissue (muscle, liver, heart, cultured skin fibroblasts), diagnostic qualitative result April 1, 2026 0615U Borrelia burgdorferi (Lyme disease), antibody detection of 26 recombinant protein groups, by immunoassay, IgM April 1, 2026 0616U Neurology (dementia), DNA methylation analysis of more than 30,000 sites, whole blood, algorithm reported as positive or negative risk April 1, 2026 0617U Cardiovascular (atherosclerotic cardiovascular disease [ASCVD]), DNA methylation analysis of more than...

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