AHA Coding Clinic® for HCPCS - 2025 Issue 3; For Your Information

New, deleted, and revised CPT Proprietary Laboratory Analyses (PLA) codes effective October 1, 2025

The most recent changes to the CPT PLA codes include 25 additions, 2 deletions and 2 revisions. New CPT PLA codesCPT Code Long Descriptor Effective Date 0575U Transplantation medicine (liver allograft rejection), miRNA gene expression profiling by RT-PCR of 4 genes (miR-122, miR-885, miR-23a housekeeping, spike-in control), serum, algorithm reported as risk of liver allograft rejection October 1, 2025 0576U Transplantation medicine (liver allograft rejection), quantitative donor-derived cell-free DNA (cfDNA) by whole genome next-generation sequencing, plasma and mRNA gene expression profiling by multiplex real-time PCR of 56 genes, whole blood, combined algorithm reported as a rejection risk score...

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