AHA Coding Clinic® for HCPCS - 2025 Issue 4; For Your Information

New, Deleted and Revised CPT Proprietary Laboratory Analyses (PLA) codes Effective January 1, 2026

The most recent changes to the CPT PLA codes include 14 additions, 10 deletions and 5 long descriptor revisions. New CPT PLA CodesCPT Code Long Descriptor Effective Date 0600U Infectious disease (wound infection), identification of 65 organisms and 30 antibiotic resistance genes, wound swab, real-time PCR, reported as positive or negative for each organism January 1, 2026 0601U Infectious disease (periprosthetic joint infection), analysis of 11 biomarkers (alpha defensins 1–3, C-reactive protein, microbial antigens for Staphylococcus [SPA, SPB], Enterococcus, Candida, and C. acnes, total nucleated cell count, percent neutrophils, RBC count, and absorbance at 280 nm) using...

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