Hypercholesterolemia

Code E78.0, Pure hypercholesterolemia, has been expanded to create code E78.00, Pure hypercholesterolemia, unspecified, and code E78.01, Familial hypercholesterolemia, in order to improve detection and screening in patients with this treatable condition. Familial hypercholesterolemia (FH) is a common autosomal dominant genetic disorder that impairs the body’s ability to remove low density lipoprotein (LDL), the “bad cholesterol” that causes blockage of the coronary arteries. The condition may be inherited from one parent with heterozygous FH (HeFH) or in the most severe form, results when both parents have an FH mutation, homozygous FH (HoFH). Optimal LDL...

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Note:  The following article synopsis was NOT provided by the AHA. It was created by Find-A-Code/innoviHealth.

Article Overview

This article covers an ICD-10-CM change related to hypercholesterolemia along with a clinical discussion of familial hypercholesterolemia, its genetic basis, signs, risk implications, and treatment approaches. It is relevant to coding professionals, clinicians, and auditors who need to understand how the condition is being categorized and why the update matters for detection and screening.

Why This Topic Matters

The topic affects diagnosis reporting and documentation for a condition associated with early cardiovascular risk and genetic testing. It helps readers understand the broader clinical context behind the ICD-10-CM coding update and the kinds of information typically documented when this disorder is evaluated.

What You Will Learn

  • How the article frames the ICD-10-CM expansion of hypercholesterolemia coding
  • The clinical background of familial hypercholesterolemia and related inherited forms
  • Common signs, laboratory patterns, and complications associated with the condition
  • General approaches to management and severe-case treatment options

Who Should Read This

  • Medical coders
  • Coding auditors
  • Clinical documentation staff
  • Physicians
  • Genetics-related healthcare professionals

Codes Discussed


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