Injection or Infusion of Glucarpidase

Effective October 1, 2012, a new procedure code (00.95) has been created to describe the administration of glucarpidase (Voraxaze®) used to treat cancer patients with toxic levels of methotrexate in their blood due to renal impairment. Prior to this change, the injection or infusion of glucarpidase was assigned to code 99.29, Injection or infusion of other therapeutic or prophylactic substance. Methotrexate is one of the most commonly used anti-cancer agents. The administration of high dose methotrexate is an important component in the treatment of a variety of cancers. One of the side effects of administering methotrexate...

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Note:  The following article synopsis was NOT provided by the AHA. It was created by Find-A-Code/innoviHealth.

Article Overview

This article covers a procedure coding update tied to glucarpidase (Voraxaze®) administration and its use in the setting of toxic methotrexate levels associated with renal impairment. It also provides the broader clinical context behind the update and identifies the earlier code used before the new procedure code took effect. The content is relevant to coding professionals and clinicians working with oncology-related hospital procedure coding.

Why This Topic Matters

It helps readers understand a specific procedure code change, the clinical scenario that prompted it, and the transition from the prior coding assignment to the updated code. This is important for accurate procedure reporting in oncology and inpatient coding workflows.

What You Will Learn

  • The clinical context associated with glucarpidase administration
  • That a procedure coding update took effect on a specified date
  • How the article frames the change in relation to prior coding practice
  • Why the update is relevant to oncology-related procedure reporting

Who Should Read This

  • Hospital coders
  • Inpatient coding specialists
  • Oncology coding professionals
  • Clinical documentation staff

Codes Discussed

  • ICD-10-PCS: 00.95
  • ICD-10-PCS: 99.29

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