Coding Brief: New Code for TPMT Enzyme-activity Test (April 2023)

April 2023 pages 18-19 Coding Brief: New Code for TPMT Enzyme-activity Test For the Current Procedural Terminology (CPT®) 2023 code set, a new code (84433) was established within the Chemistry subsection of the Pathology and Laboratory section to describe enzyme-activity testing for thiopurine S-methyltransferase (TPMT). Prior to 2023, no specific code was available to describe this enzyme-activity test; therefore, the non-specific enzyme-activity procedure code 82657 was reported. This coding brief provides an overview of the new code 84433 and its appropriate usage. Chemistry  84433 Thiopurine S-methyltransferase (TPMT) Azathioprine (AZA), 6-mercaptourine (6-MP), and 6-thioguanine (6-TG) are all substrates for...

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Note:  The following article synopsis was NOT provided by the AMA. It was created by Find-A-Code/innoviHealth.

Article Overview

This article reviews a CPT 2023 laboratory coding update focused on TPMT enzyme-activity testing. It is aimed at coding professionals, laboratory billing teams, and clinicians who need to understand the scope of the new reporting option, how it fits within the Pathology and Laboratory section, and the general distinction between enzyme-activity testing and related genetic analysis. The piece also includes a clinical example and procedure description to illustrate the kind of service the update addresses.

Why This Topic Matters

Understanding this update helps readers recognize when a newer CPT laboratory code is relevant and how it differs from other TPMT-related testing categories. It is useful for accurate lab claim reporting, documentation alignment, and communication between ordering providers and coding staff.

Article Sections

  1. April 2023 pages 18-19

    Publication context for the coding brief and its placement in the referenced issue pages.

What You Will Learn

  • What the article covers in the CPT 2023 coding update
  • How the TPMT testing topic is situated within laboratory coding
  • The general relationship between enzyme-activity testing and related laboratory/genetic services
  • Why a clinical example and procedure description are included in the brief

Who Should Read This

  • Medical coders
  • Outpatient and laboratory billing staff
  • Pathology and laboratory coding specialists
  • Compliance and reimbursement staff
  • Ordering clinicians involved in TPMT testing

Codes Discussed


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