Pathology and Laboratory: GSPs and Other Molecular Multianalyte Assays (Q&A) (December 2018)

December 2018 page 10c Pathology and Laboratory: GSPs and Other Molecular Multianalyte Assays Question: What is the appropriate CPT code to report promoter methylation analysis of BRCA1 and RAD51C performed via pyrosequencing using DNA isolated from formalin-fixed paraffin-embedded (FFPE) tumor tissue? Code 81287, MGMT (O-6-methylguanine-DNA methyltransferase) (eg, glioblastoma multiforme), methylation analysis, seems to be the closest description because it indicates methylation in the descriptor language; however, it specifically states "MGMT." Answer: Currently there is no specific CPT code that accurately describes this service. The CPT code set instructions specifically state that selecting a code that merely approximates the...

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Note:  The following article synopsis was NOT provided by the AMA. It was created by Find-A-Code/innoviHealth.

Article Overview

This article addresses a coding question in pathology and laboratory medicine related to molecular multianalyte assay reporting. It is aimed at coders and billing professionals who work with molecular pathology services and need to understand how CPT guidance applies to a specific laboratory method and specimen type. The discussion centers on code selection considerations, unlisted procedure reporting, and the type of documentation that may be needed when a direct code match is not available.

Why This Topic Matters

Accurate reporting of molecular pathology services affects claim submission, documentation support, and compliance with CPT guidance. This article is relevant for professionals evaluating whether a specific service has a direct CPT match or requires an unlisted procedure approach.

Article Sections

  1. December 2018 page 10c

    A dated article page reference introducing the topic within CPT Assistant.

  2. Pathology and Laboratory: GSPs and Other Molecular Multianalyte Assays

    A Q&A format discussion focused on molecular pathology services and related coding considerations.

What You Will Learn

  • How the article frames a molecular pathology coding question in a Q&A format.
  • What general type of CPT guidance is discussed for a specialized laboratory service.
  • Why documentation may be relevant when a direct code match is not available.
  • How the article situates the topic within pathology and laboratory coding guidance.

Who Should Read This

  • Pathology coders
  • Laboratory billing staff
  • Medical coding professionals
  • Compliance staff
  • Revenue cycle professionals

Codes Discussed


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