Reporting Primary-Source Organisms and Antibiotic-Resistance Testing (87513, 87564)

June 2025 page 5 Reporting Primary-Source Organisms and Antibiotic-Resistance Testing (87513, 87564) For the CPT 2025 code set, two Category I codes (87513, 87564) were established to report new resistance testing for Helicobacter pylori (H. pylori) and Mycobacterium tuberculosis. This article provides an overview of the intent and appropriate reporting of these new codes. Microbiology 87513 Infectious agent detection by nucleic acid (DNA or RNA); Helicobacter pylori (H. pylori), clarithromycin resistance, amplified probe technique (For H. pylori, stool, use 87338) (For H. pylori, immunoassay, use 87339) (For assays that detect clarithromycin resistance and identify H. pylori using a single...

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Note:  The following article synopsis was NOT provided by the AMA. It was created by Find-A-Code/innoviHealth.

Article Overview

This article explains the purpose and reporting context for two new CPT 2025 microbiology codes used for organism detection alongside resistance testing. It is written for coding professionals, lab staff, and others who need to understand the scope of the new reporting options, how they fit into the microbiology subsection, and the kinds of clinical scenarios and procedural workflows they address.

Why This Topic Matters

These code changes affect how certain microbiology assays are reported when organism identification and resistance-related testing are performed together in a single procedure. Understanding the article helps coding and laboratory professionals recognize when the new CPT 2025 reporting framework applies and how it differs from prior analyte-focused testing.

Article Sections

  1. June 2025 page 5

    Publication context and article placement within a June 2025 coding update.

  2. Reporting Primary-Source Organisms and Antibiotic-Resistance Testing (87513, 87564)

    Overview of the topic, including the introduction of new CPT 2025 microbiology reporting for organism detection paired with resistance testing.

  3. Microbiology

    Presentation of the relevant microbiology subsection entries and the surrounding reporting context for the new codes.

  4. Clinical Example (87513) / Description of Procedure (87513)

    A combined example and procedure description showing a typical clinical scenario associated with one of the new assays.

  5. Clinical Example (87564) / Description of Procedure (87564)

    A combined example and procedure description showing a typical clinical scenario associated with the other new assay.

What You Will Learn

  • The purpose of the new CPT 2025 microbiology reporting additions
  • How the article frames primary-source organism testing with resistance analysis
  • The kinds of clinical and laboratory scenarios the article uses to illustrate reporting context
  • How the new material is positioned relative to prior microbiology testing approaches

Who Should Read This

  • Medical coders
  • Laboratory billing staff
  • Microbiology laboratory professionals
  • Compliance teams
  • Clinical documentation staff

Codes Discussed


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