Injection or Infusion of biological response modifier as an antineoplastic agent

There are no specific codes which identify immunotherapy for cancer. It is currently being assigned to 99.25, Injection or infusion of cancer chemotherapeutic substance. Effective October 1, 1994, a new code (99.28, Injection or infusion of biological response modifier [BRM] as an antineoplastic agent), has been added to specifically identify immunotherapy. Immunotherapy is also known as biologic therapy and biologic anticancer therapy. Chemotherapy is a treatment which interferes with cell growth and division, while immunotherapy causes the body's own immune system to reject the cancer. Immunotherapy boosts the body's disease fighting mechanisms so only cancerous or other...

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Note:  The following article synopsis was NOT provided by the AHA. It was created by Find-A-Code/innoviHealth.

Article Overview

This premium article covers how immunotherapy for cancer was addressed in diagnosis coding guidance, including the addition of a specific code in 1994 and a clarification notice tied to Coding Clinic references. It is relevant to inpatient and outpatient coding professionals, coders working with oncology services, and anyone needing to understand historical reporting guidance for cancer-related immune treatments.

Why This Topic Matters

It helps readers understand historical coding guidance for cancer immunotherapy, including how a specific reporting code was introduced and how principal diagnosis assignment was clarified for admissions involving immunotherapy.

What You Will Learn

  • How immunotherapy for cancer was addressed in historical coding guidance
  • What code update was added effective October 1, 1994
  • What clarification notice is referenced in relation to Coding Clinic guidance
  • How the article frames diagnosis assignment for admissions involving immunotherapy

Who Should Read This

  • Inpatient coders
  • Outpatient coders
  • Oncology coding staff
  • Clinical documentation and coding professionals

Codes Discussed

  • ICD-9-CM: 99.25
  • ICD-9-CM: 99.28

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