AHA Coding Clinic® for ICD-10-CM and ICD-10-PCS - 2025 Issue 4; New/Revised ICD-10-CM Codes
Nephritic or Nephrotic Syndrome with Idiopathic and Secondary Immune Membranoproliferative Glomerulonephritis, and Hereditary Nephropathy
Categories N00, Acute nephritic syndrome, N04, Nephrotic syndrome, and N07, Hereditary nephropathy, not elsewhere classified, have been expanded, with the creation of the following new codes:N00.B1 Acute nephritic syndrome with idiopathic immune membranoproliferative glomerulonephritis (IC-MPGN) N00.B2 Acute nephritic syndrome with secondary immune complex membranoproliferative glomerulonephritis (IC-MPGN) N04.B1 Nephrotic syndrome with idiopathic immune complex membranoproliferative glomerulonephritis (IC-MPGN) N04.B2 Nephrotic syndrome with secondary immune complex membranoproliferative glomerulonephritis (IC-MPGN) N07.B Hereditary nephropathy, not elsewhere classified with APOL1-mediated kidney disease [AMKD] Membranoproliferative glomerulonephritis (MPGN) is a kidney disorder that is characterized by structural changes in the capillary walls...
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Article Overview
This article explains an update to ICD-10-CM within the nephrology chapter, focusing on expanded categories for nephritic syndrome, nephrotic syndrome, and hereditary nephropathy. It provides clinical background on immune complex membranoproliferative glomerulonephritis and APOL1-mediated kidney disease, including broad distinctions in presentation, etiology, and associated conditions. The content is relevant to coders, CDI specialists, auditors, and clinicians who work with kidney-related diagnoses and need to understand the scope of the new classification changes.
Why This Topic Matters
Diagnosis code updates can affect documentation review, code assignment, and data reporting for kidney disease cases. Understanding the broader clinical context helps users recognize when the revised ICD-10-CM categories may apply.
Article Sections
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Expanded nephritic, nephrotic, and hereditary nephropathy categories
Introduces the updated diagnosis categories and the creation of new ICD-10-CM codes within the nephrology section. The section frames the article’s scope around kidney disease classification changes.
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Membranoproliferative glomerulonephritis and immune complex disease background
Provides general clinical background on membranoproliferative glomerulonephritis and its immune complex-related forms. It discusses broad presentation, diagnosis, and clinical context.
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APOL1-mediated kidney disease overview
Summarizes APOL1-mediated kidney disease and its association with inherited variants and broader kidney disease patterns. The section also notes general symptoms and treatment context.
What You Will Learn
- The scope of the ICD-10-CM nephrology category expansion
- How the article frames immune complex membranoproliferative glomerulonephritis in general terms
- What broad clinical context is provided for APOL1-mediated kidney disease
- Which types of kidney-related diagnoses are covered by the update
Who Should Read This
- Medical coders
- Coding auditors
- Clinical documentation integrity specialists
- Nephrology clinicians
- Health information management professionals
Codes Discussed
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