AMA CPT® Assistant - 2020 Issue 3 (March)

Coding Update: PALB2 Gene Test (March 2020)

March 2020 page 13 Coding Update: PALB2 Gene Test For 2020, two new codes (81307, 81308) were established in the Pathology and Laboratory/Molecular Pathology subsection of the Current Procedural Terminology (CPT®) code set to describe PALB2 gene analysis as an additional partner and localizer for BRCA2, which is a gene that encodes for proteins that suppress tumors. Prior to 2020, this genetic analysis was reported using Tier 2 code 81406, which did not include testing for known familial variants. However, the frequency of testing for mutations of this gene has sufficiently increased to warrant Tier 1 status for...

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CPT® Assistant content is the official source for CPT® coding guidance. It is an instrumental tool when appealing insurance denials and validating coding to auditors. Monthly issues and an extensive archive provide comprehensive guidance on proper CPT® coding for past, present and upcoming code set releases. Archives date back to 1990 for historical use of codes, changes, rationales, coding tips and trends in the industry.

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