Updates to Molecular Pathology Codes for BRCA1, BRCA2 (May 2019)

May 2019 pages 5-6 Updates to Molecular Pathology Codes for BRCA1, BRCA2 Significant changes were made in the Molecular Pathology subsection of the 2019 Current Procedural Terminology (CPT®) code set. These changes were made to improve and update the coding structure, as well as to reflect changing landscapes in clinical practice and improvements to diagnostic laboratory services. This article discusses the comprehensive changes made to the codes for reporting tests for breast cancer susceptibility genes 1 and 2 (BRCA1, BRCA2). Molecular Pathology #81162BRCA1 (BRCA1, DNA repair associated), BRCA2 (BRCA2, DNA repair associated) (eg, hereditary breast and ovarian cancer)...

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Note:  The following article synopsis was NOT provided by the AMA. It was created by Find-A-Code/innoviHealth.

Article Overview

This premium article explains the 2019 Current Procedural Terminology (CPT) molecular pathology changes affecting BRCA1 and BRCA2 testing. It is aimed at coding, billing, and laboratory professionals who need to understand how the code set was restructured and what accompanying editorial notes, deletions, and replacements were introduced. The article also includes clinical examples and procedure descriptions to illustrate the updated testing categories.

Why This Topic Matters

BRCA1 and BRCA2 testing is commonly used in hereditary cancer evaluation, so coding updates can affect laboratory reporting, claim accuracy, and compliance. Understanding the revised molecular pathology structure helps stakeholders align documentation and test reporting with the current CPT framework.

Article Sections

  1. Molecular Pathology

    Overview of the CPT molecular pathology updates affecting BRCA1 and BRCA2 testing. Covers the restructuring of the code family, related parenthetical guidance, and examples of how the article organizes the updated reporting categories.

  2. Clinical Example (81162) / Description of Procedure (81162)

    Illustrative scenario and procedural overview associated with one BRCA1/BRCA2 testing category. Focuses on the type of laboratory workflow and testing context addressed in the article.

  3. Clinical Example (81163) / Description of Procedure (81163)

    Illustrative scenario and procedural overview associated with a BRCA testing category focused on sequence analysis. Provides context for the laboratory methods discussed in the article.

  4. Clinical Example (81164) / Description of Procedure (81164)

    Illustrative scenario and procedural overview associated with a BRCA testing category focused on duplication/deletion analysis. Describes the kind of laboratory work referenced in the article.

  5. Clinical Example (81165) / Description of Procedure (81165)

    Illustrative scenario and procedural overview associated with a BRCA1-specific testing category. Highlights the clinical and laboratory context used to explain the update.

  6. Clinical Example (81166) / Description of Procedure (81166)

    Illustrative scenario and procedural overview associated with a BRCA1 duplication/deletion category. Shows how the article presents the updated testing structure in practice.

  7. Clinical Example (81167) / Description of Procedure (81167)

    Illustrative scenario and procedural overview associated with a BRCA2 duplication/deletion category. Provides the final example used to illustrate the code revisions.

  8. Reference

    Citation information supporting the article's discussion of BRCA1 and BRCA2 molecular pathology updates.

What You Will Learn

  • How the 2019 CPT molecular pathology section changed for BRCA1 and BRCA2 testing
  • Which parts of the code family were revised, deleted, or newly established
  • How the article presents associated parenthetical notes and clinical examples
  • What laboratory and documentation contexts are highlighted for the updated testing categories

Who Should Read This

  • Medical coders
  • Pathology laboratory staff
  • Billing and reimbursement professionals
  • Compliance teams
  • Genetic testing and molecular diagnostics professionals

Codes Discussed

Code Ranges Discussed


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