Pathology and Laboratory: Multianalyte Assays with Algorithmic Analyses (Q&A) (April 2018)

April 2018 page 11b Pathology and Laboratory: Multianalyte Assays with Algorithmic Analyses Question: Would CPT code 81420, 81507, or 81599be the correct code for reporting a prenatal screen test for fetal aneuploidy that utilizes GSP and an algorithm, but is not listed under any of the MAAA categories? Answer: The introductory language for multianalyte assays with algorithmic analyses (MAAAs) in Appendix O states that when an analysis performed may potentially fall within a specific descriptor and the proprietary name is not included in the list provided, the MAAA unlisted code (81599) should be used. Currently, only code 81507, Fetal...

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Note:  The following article synopsis was NOT provided by the AMA. It was created by Find-A-Code/innoviHealth.

Article Overview

This April 2018 CPT Assistant Q&A addresses a pathology and laboratory coding question involving multianalyte assays with algorithmic analyses (MAAA). It discusses the relationship between a prenatal fetal aneuploidy screening test, the CPT MAAA framework, and the distinction between a listed assay, an unlisted MAAA code, and a panel described in the article. The piece is relevant to laboratory coders, pathology billing teams, and others responsible for reporting molecular and prenatal screening services.

Why This Topic Matters

Accurate identification of the applicable CPT reporting pathway affects laboratory claim submission and helps avoid misclassification of specialized prenatal molecular testing.

Article Sections

  1. April 2018 page 11b

    A short introductory heading identifying the publication page and issue context for the Q&A.

  2. Pathology and Laboratory: Multianalyte Assays with Algorithmic Analyses

    A question-and-answer discussion focused on prenatal screening services within the CPT multianalyte assay with algorithmic analyses framework and related reporting considerations.

What You Will Learn

  • How the article frames prenatal screening tests within the MAAA category
  • What general types of CPT reporting options are discussed for similar laboratory tests
  • How the article situates unlisted versus listed assay reporting at a high level
  • Why the distinction between algorithm-based and non-algorithm-based reporting matters for laboratory coding

Who Should Read This

  • Laboratory coders
  • Pathology billing staff
  • Revenue cycle professionals
  • Compliance teams
  • Molecular diagnostics billing specialists

Codes Discussed


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