AHA Coding Clinic® for HCPCS - 2025 Quarter 1; For Your Information
New CPT Proprietary Laboratory Analyses (PLA) codes effective April 1, 2025
New CPT PLA codes CPT code Long descriptor Effective date 0529U Hematology (venous thromboembolism [VTE]), genome-wide single nucleotide polymorphism variants, including F2 and F5 gene analysis, and Leiden variant, by microarray analysis, saliva, report as risk score for VTE April 1, 2025 0530U Oncology (pan-solid tumor), ctDNA, utilizing plasma, next-generation sequencing (NGS) of 77 genes, 8 fusions, microsatellite instability, and tumor mutation burden, interpretative report for single-nucleotide variants, copy-number alterations, with therapy association April 1, 2025 0531U Infectious disease (acid-fast bacteria and invasive fungi), DNA (673 organisms), next-generation sequencing, plasma April 1, 2025 0532U Rare diseases (constitutional disease/hereditary disorders)...
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Article Overview
This article presents a CPT PLA code update effective April 1, 2025, covering newly added laboratory analyses across oncology, infectious disease, nephrology, transplantation, cardiovascular disease, neurology, hematology, drug metabolism, and other specialties. It is useful for coding, billing, compliance, laboratory operations, and revenue cycle teams who need to identify newly effective PLA code additions and understand the general scope of the assays involved. The article is primarily a code listing with effective dates and broad test categories.
Why This Topic Matters
PLA code updates can affect test reporting, claim accuracy, charge capture, and internal billing workflows. Knowing which new codes became effective helps organizations keep laboratory and coding resources aligned with current CPT guidance.
What You Will Learn
- Which clinical areas are represented in the new CPT PLA code update
- How the article is organized around effective-date listings
- What kinds of laboratory test categories are included in the update
- Which specialties and laboratory disciplines are affected by the April 1, 2025 effective date
Who Should Read This
- Medical coders
- Pathology and laboratory billing staff
- Revenue cycle teams
- Compliance staff
- Laboratory directors
- Practice administrators
Codes Discussed
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