Updates for GSPs and Other Molecular Multianalyte Assays (May 2023)

May 2023 pages 11-17 Updates for GSPs and Other Molecular Multianalyte Assays Important changes were made in the Pathology and Laboratory section of the Current Procedural Terminology (CPT®) 2023 code set. This article will discuss several of these changes, including those made to the introductory guidelines of the Genomic Sequencing Procedures and Other Molecular Multianalyte Assays subsection. Three new codes (81449, 81451, 81456) were established for targeted genomic sequence analysis of ribonucleic acids (RNAs) and codes 81445, 81450, and 81455 were revised. Genomic Sequencing Procedures and Other Molecular Multianalyte Assays Genomic sequencing procedures (GSPs) and other molecular multianalyte...

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Note:  The following article synopsis was NOT provided by the AMA. It was created by Find-A-Code/innoviHealth.

Article Overview

This article explains recent CPT® Pathology and Laboratory section changes related to genomic sequencing procedures and other molecular multianalyte assays. It is intended for coding professionals and clinical staff who work with molecular pathology, especially those needing to understand how updated CPT® guidance organizes DNA and RNA testing scenarios and related reporting options. The article also includes clinical examples and procedural descriptions to illustrate the kinds of cases addressed by the updated code structure.

Why This Topic Matters

These updates affect how molecular pathology services are categorized and reported in the CPT® code set. Accurate awareness of the revisions helps support consistent code selection, better alignment with current clinical practice, and clearer reporting for laboratories and practices that perform genomic sequence analysis.

Article Sections

  1. May 2023 pages 11-17

    Introductory page reference for the article content.

  2. Genomic Sequencing Procedures and Other Molecular Multianalyte Assays

    Overview of the subsection topic and the general types of molecular sequencing services discussed in the update.

  3. Clinical Example and Description of Procedure

    A series of illustrative scenarios paired with procedural descriptions showing the kinds of molecular testing situations addressed by the updated code structure.

What You Will Learn

  • How the article frames the CPT® 2023 updates in the molecular pathology section.
  • What categories of genomic sequencing procedures and multianalyte assays are discussed.
  • How the article presents the relationship between revised and newly established code families.
  • What kinds of clinical examples are used to illustrate the updated guidance.

Who Should Read This

  • Medical coders
  • Coding auditors
  • Laboratory billing staff
  • Molecular pathology professionals
  • Compliance and reimbursement staff

Codes Discussed


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