AMA CPT® Assistant - 2016 Issue 9 (September)

Pathology and Laboratory: Molecular Pathology (Q&A) (September 2016)

September 2016 page 10a Pathology and Laboratory: Molecular Pathology Question: What is the appropriate CPT code to report the next generation sequencing (NGS) and analysis of data described in the following scenario? A patient sample has been extracted and prepared for exome sequencing through a next-generation sequencer that will produce genetic data for over 3,000 targeted clinical genes. The output is analyzed for NGS artifacts (false positives), coverage (accuracy), and sensitivity (false negatives). A clinical test is ordered for a subset of 300 genes within the total of 3,000 genes, in which the Guanidinoacetate N-Methyltransferase (GAMT) gene...

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