AMA CPT® Assistant - 1999 Issue 12 (December)

Pathology and Laboratory, 84153, 84154, 86316 (Q&A) (December 1999)

December 1999 page 10 Coding Consultation Pathology and Laboratory, 84153, 84154 (Q&A) Question How do you code for fractionated prostate specific antigen tests? AMA Comment Prostate specific antigen (PSA) is a serine protease that exists in the serum both in a free form (fPSA) and complexed with other protein forms. The majority of PSA is complexed with alpha-1-chymotrypsin (cPSA) with an additional immunologically unmeasurable fraction bound to alpha-2-macroglobulin. Over the years, total PSA (tPSA) testing has been useful in screening for prostate carcinoma as well as monitoring men with prostate cancer. However, tPSA testing alone lacks specificity to...

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