AMA CPT® Assistant - 2018 Issue 12 (December)

Pathology and Laboratory: GSPs and Other Molecular Multianalyte Assays (Q&A) (December 2018)

December 2018 page 10c Pathology and Laboratory: GSPs and Other Molecular Multianalyte Assays Question: What is the appropriate CPT code to report promoter methylation analysis of BRCA1 and RAD51C performed via pyrosequencing using DNA isolated from formalin-fixed paraffin-embedded (FFPE) tumor tissue? Code 81287, MGMT (O-6-methylguanine-DNA methyltransferase) (eg, glioblastoma multiforme), methylation analysis, seems to be the closest description because it indicates methylation in the descriptor language; however, it specifically states "MGMT." Answer: Currently there is no specific CPT code that accurately describes this service. The CPT code set instructions specifically state that selecting a code that merely approximates the...

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